This is a short, but important, point if you (and your medical practitioner) are considering using GLP-1 agonists like Ozempic, Wegovy or Mounjaro.

One of the mechanisms of action of the GLP-1 agonists is to encourage the secretion of insulin, the blood sugar storage hormone.

To put it very simply, both our homegrown GLP-1 and the GLP-1 agonists kickstart the following sequence of events:

But carriers of a SNP or variant on a gene called TCF7L2 may not be good candidates for using a GLP-1 agonist. For TCF7L2 the genetic SNP or variant is the presence of the “T” allele in your version of that gene.  

The research tells us that the “T” allele on TCF7L2 is a strong predictor of developing type 2 diabetes and gestational diabetes. The “T” allele is associated with higher baseline total and active GLP-1 levels. So, the problem isn’t a lack of GLP-1. The problem is that in individuals with the “T” allele, the homegrown GLP-1 or a GLP-1 agonist does not enthusiastically kickstart the sequence of events described above. So putting more GLP-1 into your system may well be “the less desirable therapeutic choice” (PMC5829963).

How do you know if you carry the “T” allele on TCF7L2? You can run the Lifecode Gx Metabolics Report. If you are struggling with blood glucose control, regulating your appetite, cholesterol, weight gain, inflammation and energy levels, the knowledge gained from running your own Metabolics report can be life-changing. Rather than stabbing in the dark and hoping for the best, you will know where your genetic weaknesses lie and, with my help, what to do about them. 

The process could not be easier:

• book a free Zoom call with me using the button below.

• As soon as we have met, I will place the order for the Metabolics report for you.

• The testing kit will be sent to you directly by Lifecode Gx.

• You just have to rub the swab firmly against the inside of your cheek and put it in the tube provided.

• Sign the consent form and post the swab and the consent form back to Lifecode Gx.

• The report will be available approximately 2-3 weeks from the date upon which Lifecode Gx receive your swab.

• As soon as the report is ready, I will contact you to arrange our consultation when I will go through your report with you and explain how to work with your genes to optimise your health and longevity.